Defining a Cancer Dependency Map

Defining Strategic Dependency Situations in Requirements Elicitation

Recently, there has been a growing interest in the Agent-oriented paradigm to cope with the needs imposed by nowadays complex and networked systems. Developing Multi-Agent Systems (MAS) calls for addressing aspects such as interaction, autonomy, collaboration and pro-activeness. One way to cope with these needs is to have agency properties as well as intentionality in the center of the software...

The cancer cell map initiative: defining the hallmark networks of cancer.

Progress in DNA sequencing has revealed the startling complexity of cancer genomes, which typically carry thousands of somatic mutations. However, it remains unclear which are the key driver mutations or dependencies in a given cancer and how these influence pathogenesis and response to therapy. Although tumors of similar types and clinical outcomes can have patterns of mutations that are strik...

Dependency Analysis as a Heat Map for Architecture Standardization

Heavy duty trucks are high variant products with a comparably small production volume per product family. A high degree of specialization regarding utilization scenarios and transportation tasks, as well as strong spreading of functional variability generate increasing numbers of offered variants. The continuous introduction of new legal, technical and customer requirements combined with long p...

Three-Dimensional Gene Map of Cancer Cell Types: Structural Entropy Minimisation Principle for Defining Tumour Subtypes

In this study, we propose a method for constructing cell sample networks from gene expression profiles, and a structural entropy minimisation principle for detecting natural structure of networks and for identifying cancer cell subtypes. Our method establishes a three-dimensional gene map of cancer cell types and subtypes. The identified subtypes are defined by a unique gene expression pattern,...

Cancer Antigen Prioritization: A Road Map to Work in Defining Vaccines Against Specific Targets. A Point of View